Announcements
Wake Forest Pepper Center Early Career Faculty Scholar Positions – Request for Applications (RFA) The Research Education Core (REC) of the Wake Forest Claude D. Pepper Older Americans Independence Center seeks applications from early career faculty to support their development into independent scientists with an interest in aging, diseases that affect function in older adults, and interventions that integrate pathways affecting physical function for new approaches to disability prevention. Faculty members with an interest in basic, clinical, translational, or population research are invited to apply. Protected research time (2-3yrs support – typical) A formal mentoring team Priority access to Pepper Center Research Support Cores and resources Travel funds Informational sessions will be held on Wednesday, Feb 24th (5pm) and Friday, Feb 26th (12 noon) RSVP to Laura Hayworth (lhayworth@wakehealth.edu ) by Monday, Feb 22nd to confirm attendance and receive a meeting link. Application Deadline: April 2, 2021 If interested, please email Laura Hayworth lhayworth@wakehealth.edufor applications instructions. In the email indicate your Dept/Sec, current academic rank, and your area of interest.
WFSOM – COVID-19 Research Assistance Fund RFA The goal of these funds is to assist ongoing research teams that have been negatively impacted by the COVID-19 pandemic. This funding mechanism is open to all research types, ranging from fundamental basic science to population-based teams. Applications to support negatively impacted projects that are interdisciplinary, related to Academic Learning Health System, or focused on health equity research are encouraged Projects must clearly document 1) the impact of COVID-19 on the team’s ongoing research portfolio, and 2) how these funds will provide a catalyst for future success. $50,000 in direct costs. All funds to be spent within a 1-yr period. Full Application Deadline is May 2nd Full info: https://wakehealth.us18.list-manage.com/track/click?u=94c31ea49a1f4fdcae1168ad4&id=1a64689103&e=e983df7115&utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=a4c5711217-EMAIL_CAMPAIGN_2020_04_14_08_58_COPY_01&utm_medium=email&utm_term=0_9d8dbeb58a-a4c5711217-
United Mitochondrial Disease Foundation – 2021 Postdoctoral Fellowship (accelerators) Prize – RFA The UMDF Trustees have identified training junior members of the mitochondrial disease research community as a priority for the current grant funding cycle with the primary goal in adding the development of the next generation of scientists dedicated to mitochondrial disease research. $50,000 total (over 2 years) Eligible investigators must be within 3 years of receiving MD, PhD or equivalent degree Award only covers salary and benefits of Postdoctoral Fellow Deadline – March 1st by 5pm Full info: https://umdf.smapply.org/prog/2021_postdoctoral_fellowship_accelerators_prize_/
Foundation, Pilot, Outside Funding Opportunities: https://ctsi.wakehealth.edu/Funding-Opportunities?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=e8db2e7181
Upcoming Events
Unite and Ignite with Julie Freischlag Date/Time: Monday, Feb 15th (12 pm – 1 pm) Speakers: Goldie Smith Byrd, PhD Dave McIntosh, PhD, MA Christopher Ohl, MD Cathleen Wheatley, DNP, RN, DENP Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=eb0372c54fea1eddebb131f31d3e8795b Password: 1234
Cancer Biology Talk Date/Time: Tuesday, Feb 16th (9 am – 10 am) Speaker: Kojo Agyemang, MS (Graduate Student – Dr. Pasche’s Lab) Title: “TGRBR1*6A as a modifier for breast tumor formation and progression” Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=m72f5d573f0eaca6ab60d2c96ee88240d Meeting #: 185 657 3801 Passcode: cHj2VsNbG36
Phys/Pharm Virtual Seminar Series Date/Time: Wednesday, Feb 17th (4 pm – 5 pm) Speaker: William Stoops, PhD Professor – Depts of Behavioral Science & Psychiatry and Psychology University of Kentucky College of Medicine Title: “Human Laboratory Outcomes and Potential Treatment Targets in Cocaine Use Disorder” Webex: Meeting #: 171 316 1571 Password: mvSftNaj252
Molecular Medicine Journal Club – MMTS 782 Date/Time: Friday, Feb 19th (10 am – 11 am) Speaker: Allison Meyers (PhD Graduate Student) Title: “Inhibition of Mitophagy Drives Macrophage Activation and Antibacterial Defense During Sepsis” Patoli, D et al., JCI, 2020;130(11):5858-5874 Link to paper: https://wakehealth.sharepoint.com/sites/MolecularMedicineResearch/Journal%20Articles/Forms/2019.aspx?viewid=fb520096%2D254c%2D457f%2Da8da%2D6c57a9dfb122&id=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles%2FJournal%20Club%202%2019%2021%2Epdf&parent=%2Fsites%2FMolecularMedicineResearch%2FJournal%20Articles Webex: https://wakehealth.webex.com/wakehealth/j.php?MTID=mf1394c0571a3b01f588f6e94016f4fb7 Meeting #: 178 615 6114 Password: CDOM
Recent Publications
Tyagi A, Sharma S, Wu K, Wu S-Y, Xing F, Liu Y, Zhao D, Deshpande RP, D’Agostino Jr RB, Watabe K. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021 Jan 20;12(1):474. PMID: 33473115. https://doi.org/10.1038/s41467-020-20733-9
Levine EA. Do You Know Cancer When You See It? Dis Colon Rectum. 2021 Jan 25. [Online ahead of print] PMID: 33496482. https://doi.org/10.1097/dcr.0000000000001958
Voorhies K, Sordillo JE, McGeachie M, *Ampleford E, Wang AL, Lasky-Su J, Tantisira K, Dahlin A, Kely RS, Ortega VE, Lutz SM, Wu AC. Age by Single Nucleotide Polymorphism Interactions on Bronchodilator Response in Asthmatics. J Pers Med. 2021 Jan 19;11(1):59. PMCID: PMC7833432. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7833432/
Teng T, Shively CA, Li X, Jiang X, Neigh GN, Yin B, Zhang Y, Fan L, Xiang Y, Wang M, Liu X, Qin M, Zhou X, Xie P. Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys. Transl Psychiatry. 2021 Jan 4;11(1):9. PMCID: PMC7791128. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7791128/
King CP, Tripi JA, Hughson AR, Horvath AP, Lamparelli AC, Holl KL, Chitre AS, Polesskaya O, Ishiwari K, Solberg Woods LC, Palmer AA, Robinson TE, Flagel SB, Meyer PJ. Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. Sci Rep. 2021 Jan 26;11(1):2223. PMID: 3350044. https://doi.org/10.1038/s41598-020-80798-w
*Deal A, Cooper N, Kirse HA, Uneri A, Raab-Graham K, Weiner JL, Solberg Woods LC. Early life stress induces hyperactivity but not increased anxiety-like behavior or ethanol drinking in outbred heterogeneous stock rats. Alcohol. 2020 Dec 13;91:41-51. PMID; 33321179 [Online ahead of print] https://doi.org/10.1016/j.alcohol.2020.11.007
Member Highlights
William Gmeiner, PhD Professor, Cancer Biology William Gmeiner is a Professor of Cancer Biology with a research focus on experimental therapeutics for treatment of cancer with an emphasis on improving outcomes for patients with metastatic colon cancer, small cell lung cancer, and other highly lethal malignancies. His research projects include developing novel fluoropyrimidine polymers (e.g. CF10), and understanding the mechanistic and pharmacological basis for achieving improved anti-tumor and anti-metastatic activities with these compounds, while decreasing systemic toxicities. He uses a variety of experimental techniques including nucleic acid chemistry, structural and computational biology, biochemical assays, and cell-, animal-, and organoid-based cancer models in conjunction with expression profiling, metabolomics, proteomics and other approaches to implement a personalized medicine approach to cancer treatment. He serves on the editorial boards of Cancers (Basel), Cancer Drug Resistance, and Precision Cancer Medicine and has served on numerous NIH and DOD review panels. He has >10 issued US and international patents and has founded two companies including Deep Creek Pharma, which was recently founded to facilitate translation of CF10 into clinical trials. He also is collaborating with the NCI Nanotechnology Laboratory (ncl.cancer.gov) on CF10 translation. At Wake Forest, he is member of the Comprehensive Cancer Center and the Center for Precision Medicine and is cross-appointed in the Department of Physiology and Pharmacology and is affiliated faculty in Molecular Medicine and Translational Science and the Wake Forest/Virginia Tech joint school of Biomedical Engineering and Sciences. Selected Publications: htps://www.ncbi.nlm.nih.gov/myncbi/william.gmeiner.1/bibliography/public/?page=1 Improved anti-Tumor activity of the fluoropyrimidine polymer CF10 in pre-clinical colorectal cancer models thru distinct mechanistic and pharmacological properties. https://pubmed.ncbi.nlm.nih.gov/33361273/ Chemistry of Fluorinated Pyrimidine in the Era of Personalized Medicine. https://pubmed.ncbi.nlm.nih.gov/32751071/ Dysregulated pyrimidine biosynthesis contributes to 5-FU resistance in SCLC patient-derived organoids but response to a novel polymeric fluoropyrimidine, CF10. https://pubmed.ncbi.nlm.nih.gov/32224870/ Thymineless death by the fluoropyrimidine polymer F10 involves replication fork collapse and is enhanced by Chk1 inhibition. https://pubmed.ncbi.nlm.nih.gov/30439567/ Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. https://pubmed.ncbi.nlm.nih.gov/30613833/