Announcements
JOINT RFA Translational Research Initiative – Joint Pilot The primary focus of the RFA is to encourage the development of interdisciplinary research teams for translational research involving collaborators across the new Atrium Health Enterprise Six projects will be funded and will receive up to $40,000 in direct costs. Funds are to be spent within a 1-year project period. Info Link: https://ctsi.wakehealth.edu/Announcements/2020/11/Joint-RFA-2020?utm_source=Master+Research+Rundown+%26+Funding&utm_campaign=50968228aa-EMAIL_CAMPAIGN_2020_11_30&utm_medium=email&utm_term=0_9d8dbeb58a-50968228aa-194798127
Internal/External/Foundation Funding Opportunities https://ctsi.wakehealth.edu/Funding-Opportunities
Upcoming Events
Center for Diabetes, Obesity, and Metabolism – Virtual Seminar Series Date/Time: Monday, Dec 7th – 4pm – 5pm Presenter: Dr. Deepak Palakshappa Assistant Professor, General Internal Medicine Assistant Professor, Pediatrics Assistant Professor, Epidemiology and Prevention Talk Title: “The Growing Recognition of the Impact of Food Insecurity on Health” WebEx Info: Meeting #: 171 088 8247 Password: cdom
Aging Center Journal Club – WebEx Date/Time: Wednesday, Dec 9th – 1:00pm – 2:00pm · Dr. Ryan Miller (Postdoc) “The U-Shaped Relationship Between Levels of Bouted Activity and Fall Incidence in Community-Dwelling Older Adults: A Prospective Cohort Study” https://academic.oup.com/biomedgerontology/article/75/10/e145/5770959 Dr. Katherine Seachrist (Hospice Palliative Med Fellowship) “Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437541/ WebEx Info: Join meeting Meeting #: 171 195 2750 Password: pbYYdb38MT8
Phys/Pharm Virtual Seminar Series – Webex Date/Time: Thursday, Dec 10th – 4:00pm – 5:00pm Presenter: Jurgen Rehm, PhD Senior Director of the Institute for Mental Health Policy Research Senior Scientist in the Campbell Family Metal Health Research Institute at CAMH Professor and Inaugural Chair of Addiction Policy in the Dalla Lana School of Public Health University of Toronto Talk Title: “TBA” WebEx Info: Meeting #: 171 316 1571 Password: mvSftNaj252
Recent Publications
Chouliaras K, Patel N, Senehi R, Ethun CG, Poultsides G, Grignol V, Gamblin TC, Roggin KK, Fields RC, D’Agostino Jr R, Levine EA, Cardona K, Votanopoulos K. Impact of resection margin on outcomes in high-grade soft tissue sarcomas of the extremity-A USSC analysis. J Surg Oncol. 2020 Nov. [Online ahead of print] PMID: 33150594. https://doi.org/10.1002/jso.26275
Burdette JH, Laurienti PJ, Miron LL, Bahrami M, Simpson SL, Nicklas BJ, Fanning J, Rejeski WJ. Functional Brain Networks: Unique Patterns with Hedonic Appetite and Confidence to Resist Eating in Older Adults with Obesity. Obesity (Silver Spring). 2020 Nov1. [Online ahead of print] PMID: 33135364. https://doi.org/10.1002/oby.23004
Alderawi A, Caramori G, Baker EH, Hitchings AW, Rahman I, Rossios C, Adcock I, Cassolari P, Papi A, Ortega VE, Curtis Jeffrey L, Dunmore S, Kirkham P. FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease. BMJ Open Respir Res. 2020 Nov;7(1):e000714. PMID: 33208304. https://doi.org/10.1136/bmjresp-2020-000714
Cohen JB, D’Agostino-McGowan L, Jensen ET, Rigdon J, South AM. Evaluating sources of bias in observational studies of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker use during coronavirus disease 2019: beyond confounding. J Hypertens. 2020 Nov 11. [Online ahead of print]. PMID: 33186321. https://doi.org/10.1097/hjh.0000000000002706
Wilson HL, D’Agostino Jr RB, Meegalla N, Petro R, Commander S, Topaloglu U, Zhang W, Porosnicu M. The Prognostic and Therapeutic Value of the Mutational Profile of Blood and Tumor Tissue in Head and Neck Squamous Cell Carcinoma. Oncologist. 2020 Oct 23. [Online ahead of print] PMID: 33098199. https://doi.org/10.1002/onco.13573
Member Highlights
Congratulations to Dr. Nichole Allred for winning the WFBMI Informatics Challenge.
Newly awarded grants
Kylie Kavanagh (Sub – PI) NIDDK/UNC-CH (R01 DK123206) 09.01.20 – 08.31.22 Enabling accurate identification and quantification of brown adipose tissue mass by xenon enhanced computed tomography The goal of this proposal builds upon our preliminary results in which we have shown that the inert and lipophilic gas xenon can be used as a CT contrast agent to detect and quantify BATmall.
Carl Langefeld (Co-Investigator) NIH (R01 GM134226) 09.05.20 – 06.30.24 Solid-state Nanopores for Translational Analysis of Hyaluronan Abundance and Size Distribution The goals of this project are to make strategic advancements to the existing approach that will improve its analytical value, and then apply it to translational HA diagnostics in two model systems for which extreme sensitivity will be particularly enabling due to low HA content in key biospecimens, mestastatic breast cancer (plasma), and rheumatoid arthritis (plasma and urine).
Shannon Macauley (PI) NIH/NIA (R01 AG068330) 08.01.20 – 04.30.25 The Metabolic Interplay of Sleep and Alzheimer’s Disease The goal of this project is to understand how changes in metabolism impact the relationship between sleep and Alzheimer’s disease and whether metabolic dysfunction is a novel therapeutic target for treating Alzheimer’s disease and sleep.
Shannon Macauley (PI) BrightFocus Foundation (A20201775S) 09.01.20 – 08.31.23 KATP channel inhibition as a modifier of tau pathology in Alzheimer’s disease The goal of this grant is to demonstrate that low dose treatment with the KATP channel antagonist, glyburide, reduces interstitial fluid (ISF) tau levels, tau related pathology, and functional deficits in the P301S (PS19) mouse model of tauopathy. It is also to demonstrate that glyburide treatment is sufficient to prevent tau spreading and neuritic plaque formation in the human tau-APPswe, PSEN1dE9 (APP/PS1) mouse model.